BindingDB PrimarySearch

Found 74 of ic50 data for polymerid = 7695

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)

IC50: 4nMAssay Description:Inhibition of human PRMT3 assessed as inhibition of methylation activity using biotin-labeled peptide as substrate and [3H]-SAM by scintillation prox...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase MCE
PC cid PC sid PDB

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)

Ki: 55nM IC50: 119nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase MCE
PC cid PC sid PDB

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427787(CHEMBL2325198)

IC50: 230nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427778(CHEMBL2325177)

IC50: 300nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427788(CHEMBL2325197)

IC50: 360nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427772(CHEMBL2325183)

IC50: 480nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427790(CHEMBL2325195)

IC50: 490nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427789(CHEMBL2325196)

IC50: 840nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427777(CHEMBL2325178)

IC50: 850nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427767(CHEMBL2325442)

IC50: 1.00E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)

Ki: 550nM IC50: 1.10E+3nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427768(CHEMBL2325441)

IC50: 1.60E+3nMAssay Description:Inhibition of recombinant human PRMT3 (211 to 531) using histone-4 (1 to 24) as substrate by S-adenosylhomocysteine hydrolase-coupled assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427776(CHEMBL2325179)

IC50: 1.80E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427794(CHEMBL2325191)

IC50: 1.90E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50194758(CHEMBL3970878)

IC50: 1.97E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427771(CHEMBL2325184)

IC50: 2.20E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50431676(CHEMBL2349526)

IC50: 2.30E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427768(CHEMBL2325441)

IC50: 2.40E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427770(CHEMBL2325185)

IC50: 2.70E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427775(CHEMBL2325180)

IC50: 3.10E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427791(CHEMBL2325194)

IC50: 3.30E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427796(CHEMBL2325189)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427769(CHEMBL2325186)

IC50: 3.60E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427757(CHEMBL2325163)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427774(CHEMBL2325181)

IC50: 4.00E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427792(CHEMBL2325193)

IC50: 4.40E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427793(CHEMBL2325192)

IC50: 5.00E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427756(CHEMBL2325164)

IC50: 5.20E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427797(CHEMBL2325188)

IC50: 5.30E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427795(CHEMBL2325190)

IC50: 5.90E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50328743(3-((4-acetamidophenyl)diazenyl)-4-hydroxy-7-(3-(5-...)

IC50: 7.10E+3nMAssay Description:Inhibition of His6x-tagged PRMT3-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using GAR R4 peptide and [14C]-SAM by scintil...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427754(CHEMBL2325166)

IC50: 7.20E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50387477(CHEMBL2047477)

IC50: 8.30E+3nMAssay Description:Inhibition of His6X-tagged PRMT3 expressed in Escherichia coli BL21(DE3) cells using [14C]-S-adenosyl-L-methionine and histone H4 peptide after 8 min...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427798(CHEMBL2325187)

IC50: >1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427781(CHEMBL2325174)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427755(CHEMBL2325165)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427753(CHEMBL2325167)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427785(CHEMBL2325170)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427779(CHEMBL2325176)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50353131(CHEMBL1829304)

IC50: >1.00E+4nMAssay Description:Inhibition of PRMT3 assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427780(CHEMBL2325175)

IC50: >1.50E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427782(CHEMBL2325173)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427786(CHEMBL2325169)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427783(CHEMBL2325172)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50158094(CHEMBL3780926)

IC50: 1.90E+4nMAssay Description:Inhibition of human PRMT3 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50194756(CHEMBL3961701)

IC50: >2.20E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427784(CHEMBL2325171)

IC50: >2.50E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50427773(CHEMBL2325182)

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM27659(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...)

IC50: >2.50E+4nMAssay Description:Inhibition of GST-tagged PRMT3 by methylation assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

Details Article PubMed

Protein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL

BDBM50301077(2-(4-(2-(2,6-dimethoxyphenyl)-7-methyl-1H-benzo[d]...)

IC50: >2.50E+4nMAssay Description:Inhibition of PRMT3More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Displayed 1 to 50 (of 74 total ) | Next | Last >>

Filter my 74 hits

Targets 1▿
- Protein arginine N-methyltransferase 3 [N508S] 74
Publications 17▿
- J Med Chem 56: 2110-24 (2013) 47
- J Med Chem 59: 9124-9139 (2016) 4
- J Med Chem 59: 1176-83 (2016) 4
- ACS Chem Biol 11: 772-81 (2016) 3
- ACS Med Chem Lett 3: 1091-1096 (2012) 3
- J Med Chem 53: 5844-57 (2010) 2
- Bioorg Med Chem Lett 19: 5063-6 (2009) 1
- Bioorg Med Chem 21: 1787-94 (2013) 1
- Chem Biol Drug Des 89: 585-598 (2017) 1
- J Med Chem 53: 6028-39 (2010) 1
- Eur J Med Chem 54: 647-59 (2012) 1
- Bioorg Med Chem Lett 18: 4438-41 (2008) 1
- Bioorg Med Chem Lett 19: 2924-7 (2009) 1
- J Med Chem 58: 1596-629 (2015) 1
- J Med Chem 57: 6822-33 (2014) 1
- J Med Chem 54: 6139-50 (2011) 1
- Nat Chem Biol 13: 381-388 (2017) 1
Institutions 10▿
- University Of North Carolina At Chapel Hill 51
- Icahn School Of Medicine At Mount Sinai 5
- University Of Toronto 4
- Bristol-Myers Squibb Pharmaceutical Research And Development 3
- TBA 3
- University of Toronto 3
- Georgia State University 2
- Novartis Institutes For Biomedical Research 1
- Entremed 1
- Sichuan University 1
Affinity: 4 to 1.0E+6 nM▿
- Ki 3
- IC50 74
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 16